KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SH2D5
All Species:
9.09
Human Site:
S125
Identified Species:
33.33
UniProt:
Q6ZV89
Number Species:
6
Phosphosite Substitution
Charge Score:
-0.5
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6ZV89
NP_001096630.1
339
37439
S125
P
A
E
G
L
V
G
S
G
K
E
L
P
E
S
Chimpanzee
Pan troglodytes
XP_001164984
686
74506
S472
P
A
E
G
L
V
G
S
G
K
E
L
P
E
S
Rhesus Macaque
Macaca mulatta
XP_001109069
497
54279
S283
P
A
E
G
L
V
G
S
G
K
E
L
P
E
S
Dog
Lupus familis
XP_534478
629
68321
R371
R
S
E
F
A
L
R
R
K
L
G
E
G
H
F
Cat
Felis silvestris
Mouse
Mus musculus
Q8JZW5
345
38155
K131
G
L
L
G
S
N
G
K
E
L
P
E
S
E
G
Rat
Rattus norvegicus
XP_001070433
429
47319
K215
G
L
L
G
S
N
G
K
E
L
P
E
P
E
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001232826
326
35418
V124
P
E
E
V
S
R
N
V
N
A
L
L
S
L
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
49.2
66.5
20.3
N.A.
86.6
69.6
N.A.
N.A.
33
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
49.4
66.8
30
N.A.
90.4
71.7
N.A.
N.A.
45.1
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
6.6
N.A.
20
26.6
N.A.
N.A.
20
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
20
N.A.
20
26.6
N.A.
N.A.
20
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
43
0
0
15
0
0
0
0
15
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
15
72
0
0
0
0
0
29
0
43
43
0
72
0
% E
% Phe:
0
0
0
15
0
0
0
0
0
0
0
0
0
0
15
% F
% Gly:
29
0
0
72
0
0
72
0
43
0
15
0
15
0
29
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
15
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
29
15
43
0
0
0
0
0
% K
% Leu:
0
29
29
0
43
15
0
0
0
43
15
58
0
15
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
29
15
0
15
0
0
0
0
0
0
% N
% Pro:
58
0
0
0
0
0
0
0
0
0
29
0
58
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
15
0
0
0
0
15
15
15
0
0
0
0
0
0
15
% R
% Ser:
0
15
0
0
43
0
0
43
0
0
0
0
29
0
43
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
15
0
43
0
15
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _